Saturday, January 28, 2012

Polycystic Ovarian Syndrome

Dr Deepika Tiwari, Gynecologist, Gurgaon

Women with PCOS have abnormalities in the metabolism of androgens and estrogen and in the control of androgen production. High serum concentrations of androgenic hormones, such as testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEA-S), may be encountered in these patients.
PCOS is also associated with peripheral insulin resistance and hyperinsulinemia, and obesity amplifies the degree of both abnormalities.
Patients with PCOS may present with various clinical features.
Menstrual abnormalities/ Hyperandrogenism/ Infertility/ Obesity/ Diabetes mellitus/ Sleep apnea/ Metabolic syndrome
Diet and exercise: In patients with PCOS who are obese, endocrine-metabolic parameters markedly improve after 4-12 weeks of dietary restriction. 
Metformin: This antidiabetic drug improves insulin resistance and decreases hyperinsulinemia in patients with PCOS
Patients with PCOS who are infertile but desire pregnancy should be referred to a reproductive endocrinologist for further evaluation and management of infertility.

Dr Deepika Tiwari, Gynecologist, Gurgaon 9911821669


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